Automatic respiratory phase detection for functional electrical stimulation synchronization

Abstract Introduction People with cervical or high thoracic spinal cord injury usually have respiratory muscle weakness. When transcutaneous functional electrical stimulation (TFES) synchronized with the patient's natural breathing is applied to respiratory muscles, their strength and resistance are increased. In this work, we propose a novel method to perform an automatic synchronization, composed of a signal acquisition system and an algorithm that recognizes both respiratory cycle phases during quiet breathing. Methods The respiratory signal acquisition unit consists of a load cell attached to an elastic belt. The algorithm is based on statistical evaluation and linear approximation for detecting the beginning of both inhalation and exhalation phases. Ten volunteers remained steady, breathing quietly for one minute for signal acquisition. Results The system's automatic detection of inspiratory events reached 87.5% of true positives, 6.7% of false negatives and 5.8% of false positives. Both hit and error ratios obtained in the detection of expiratory events reached 94.3% true positives, 4.9% false positives and 0.8% false negatives. Conclusion The developed algorithm can identify the respiratory phases properly and it can be used in future synchronized TFES applications whether the patient remains in a quasi-static position during treatment.

Power amplifier circuits for functional electrical stimulation systems

Abstract Introduction: Functional electrical stimulation (FES) is a technique that has been successfully employed in rehabilitation treatment to mitigate problems after spinal cord injury (SCI). One of the most relevant modules in a typical FES system is the power or output amplifier stage, which is responsible for the application of voltage or current pulses of proper intensity to the biological tissue, applied noninvasively via electrodes, placed on the skin surface or inside the muscular tissue, closer to the nervous fibers. The goals of this paper are to describe and discuss about the main power output designs usually employed in transcutaneous functional electrical stimulators as well as safety precautions taken to protect patients. Methods A systematic review investigated the circuits of papers published in IEEE Xplore and ScienceDirect databases from 2000 to 2016. The query terms were "((FES or Functional electric stimulator) and (circuit or design))" with 274 papers retrieved from IEEE Xplore and 29 from ScienceDirect. After the application of exclusion criteria the amount of papers decreased to 9 and 2 from IEEE Xplore and ScienceDirect, respectively. One paper was inserted in the results as a technological contribution to the field. Therefore, 12 papers presented power stage circuits suitable to stimulate great muscles. Discussion The retrieved results presented relevant circuits with different electronic strategies and circuit components. Some of them considered patient safety strategies or aimed to preserve muscle homeostasis such as biphasic current application, which prevents charge accumulation in stimulated tissues as well as circuits that dealt with electrical impedance variation to keep the electrode-tissue interface within an electrochemical safe regime. The investigation revealed a predominance of design strategies using operational amplifiers in power circuits, current outputs, and safety methods to reduce risks of electrical hazards and discomfort to the individual submitted to FES application.

Influence of subcutaneous fat on mechanomyographic signals at three levels of voluntary effort

Abstract Introduction This study aims to assess the influence of different skinfold thicknesses (ST) and their relation to the attenuation of the mechanomyographic (MMG) signal at different force levels (maximal voluntary contraction – MVC, 40% of MVC and 70% of MVC) of the rectus femoris muscle. Methods Fifteen volunteers were divided in two groups: ST lower than 10mm (G<10) (8 participants) and ST higher than 35mm (G>35) (7 participants). Student t tests were employed to investigate differences between G<10 and G>35 regarding MMG analysis parameters (acceleration root mean square – aRMS, zero crossing – ZC, and median frequency – MDF), for the X, Y and Z axes, as well as for the modulus of these three axes. Results We found that thicker layers of body fat act as attenuator filters for the MMG signal [MDFMVC: X (p = 0.005), Z (p = 0.003); MDF70%MVC: X (p = 0.034); ZCMVC: Z (p = 0.037), modulus (p = 0.005); ZC70%MVC: Z (p = 0.047)]. We found significant correlation between ST values and aRMS in three levels, in the Yaxis (p = 0.591), for the group G<10. For the modulus, the aRMS value showed correlation with ST values for group G>35 in 40%MVC (R2 = 0.610), and 70%MVC (R2 = 0.592). The MDF parameter showed correlation with ST values only in the Yaxis in 70%MVC (R2 = 0.700) for G>35. Conclusions We observed MMG signal attenuation in at least one of the parameters analyzed for each level of the rectus femoris muscle force, indicating that MMG signals are significantly attenuated with increasing thickness of the subcutaneous fat layer.

Artificial motor control for electrically stimulated upper limbs of plegic or paretic people

Introduction: Functional Electrical Stimulation (FES) is a technique used in the restoration and generation of movements performed by subjects with neuromuscular disorders such as spinal cord injury (SCI). The purpose of this article is to outline the state of the art and perspectives of the use of FES in artificial motor control of the upper limbs in paretic or plegic people. Methods The databases used in papers selection were Google Scholar and Capes’ Portals as well as proceedings of the Annual Conference of the International Functional Electrical Stimulation Society (IFESS). Results Approximately 85% of the reviewed studies showed FES profile with pulse duration ranging from 1 to 300 μs and modulating (burst) frequency between 10 and 40 Hz. Regarding the type of electrodes, 88% of the studies employed transcutaneous electrodes. Conclusion We concluded that FES with closed-loop feedback and feedforward are the most used and most viable systems for upper limbs motor control, because they perform self-corrections slowing neuromuscular adaptation, allowing different planes and more range of movement and sensory-motor integration. One of the difficulties found in neuroprosthesis systems are electrical wires attached to the user, becoming uninteresting in relation to aesthetics and break. The future perspectives lead to a trend to miniaturization of the stimulation equipment and the availability of wireless networks, which allow the attachment of modules to other components without physical contact, and will become more attractive for daily use.

Correlation between spectral and temporal mechanomyography features during functional electrical stimulation

Abstract Introduction: Signal analysis involves time and/or frequency domains, and correlations are described in the literature for voluntary contractions. However, there are few studies about those correlations using mechanomyography (MMG) response during functional electrical stimulation (FES) elicited contractions in spinal cord injured subjects. This study aimed to determine the correlation between spectral and temporal MMG features during FES application to healthy (HV) and spinal cord injured volunteers (SCIV). Methods: Twenty volunteers participated in the research divided in two groups: HV (N=10) and SCIV (N=10). The protocol consisted of four FES profiles transcutaneously applied to quadriceps femoris muscle via femoral nerve. Each application produced a sustained knee extension greater than 65º up to 2 min without adjusting FES intensity. The investigation involved the correlation between MMG signal root mean square (RMS) and mean frequency (MF). Results: HV and SCIV indicated that MMGRMS and MMGMF variations were inversely related with -0.12 ≥ r ≥ -0.82. The dispersion between MMGMF and MMGRMS reached 0.50 ≤ r2 ≤ 0.64. Conclusion The increase in MMGRMS and the decrease in MMGMF may be explained by the motor units coherence during fatigue state or by motor neuron adaptation (habituation) along FES application (without modification on parameters).

Advances and perspectives of mechanomyography

INTRODUCTION: The evaluation of muscular tissue condition can be accomplished with mechanomyography (MMG), a technique that registers intramuscular mechanical waves produced during a fiber's contraction and stretching that are sensed or interfaced on the skin surface. OBJECTIVE: Considering the scope of MMG measurements and recent advances involving the technique, the goal of this paper is to discuss mechanomyography updates and discuss its applications and potential future applications. METHODS: Forty-three MMG studies were published between the years of 1987 and 2013. RESULTS: MMG sensors are developed with different technologies such as condenser microphones, accelerometers, laser-based instruments, etc. Experimental protocols that are described in scientific publications typically investigated the condition of the vastus lateralis muscle and used sensors built with accelerometers, third and fourth order Butterworth filters, 5-100Hz frequency bandpass, signal analysis using Root Mean Square (RMS) (temporal), Median Frequency (MDF) and Mean Power Frequency (MPF) (spectral) features, with epochs of 1 s. CONCLUSION: Mechanomyographic responses obtained in isometric contractions differ from those observed during dynamic contractions in both passive and functional electrical stimulation evoked movements. In the near future, MMG features applied to biofeedback closed-loop systems will help people with disabilities, such as spinal cord injury or limb amputation because they may improve both neural and myoelectric prosthetic control. Muscular tissue assessment is a new application area enabled by MMG; it can be useful in evaluating the muscular tonus in anesthetic blockade or in pathologies such as myotonic dystrophy, chronic obstructive pulmonary disease, and disorders including dysphagia, myalgia and spastic hypertonia. New research becomes necessary to improve the efficiency of MMG systems and increase their application in rehabilitation, clinical and other health areas.

Relationship between peak and mean amplitudes of the stimulating output voltage for functional control of the knee by spinal cord patients and healthy volunteers

INTRODUCTION: Functional electrical stimulation (FES) may evoke movements in people with movement impairments due to neurological lesion. The mean value of electrical current or voltage during FES depends on the stimulatory profile parameters. To investigate the relationship between peak and mean amplitudes of the stimulator output voltage while causing a knee extension angle change from 90º to 40º to choose the best and safest profile to be applied in people who have suffered a spinal cord injury. METHODS: Healthy (N = 10) volunteers and those with spinal cord injuries (N = 10) participated in this study. Each FES profile (P1, P2, P3 and P4) had 1-kHz pulses (100 µs or 200 µs on and 900 µs or 800 µs off) with burst frequencies of 50 Hz (3 ms on and 17 ms off) or 70 Hz (3 ms on and 11 ms off) and peak amplitudes set between 53-125V for healthy volunteers and 68-198 V for volunteers with spinal cord injury. RESULTS: The highest mean amplitude were obtained using a FES profile with active/total pulse period of 200 us/1000 us and burst frequency of 3ms/14ms. The best results of mean amplitude were observed using a FES profile duty cycle of 10% for pulses (100 µs/1000 µs) and 15% for bursts (3 ms/20 ms). CONCLUSION: The FES profile (100 µs - 50 Hz) seems to be the most suitable for both groups, inasmuch as it presents smaller mean amplitudes and peak amplitudes similar to other FES profiles.

Potencial de ação: do estímulo à adaptação neural / Action potential: from excitation to neural adaptation

INTRODUÇÃO: O potencial de ação (PA) origina-se graças a uma perturbação do estado de repouso da membrana celular, com consequente fluxo de íons, por meio da membrana e alteração da concentração iônica nos meios intra e extracelular. OBJETIVOS: Sintetizar o conhecimento científico acumulado até o presente sobre o potencial de ação neural e o seu processo de adaptação sob aplicação de um estímulo constante. MATERIAIS E MÉTODOS: Busca realizada nas bases Springer, ScienceDirect, PubMed, IEEE Xplore, Google Acadêmico, Portal de Periódicos da Capes, além de livros referentes ao assunto. O idioma de preferência selecionado foi o inglês, com as keywords: action potential; adaptation; accommodation; rheobase; chronaxy; nerve impulse. Efetuou-se a procura de artigos com uma janela de tempo de 1931 a 2010 e livros de 1791 a 2007. RESULTADOS: Dos trabalhos selecionados, foram extraídas informações a respeito dos seguintes tópicos: potencial de ação e suas fases; condução nervosa; reobase; cronaxia; acomodação; e adaptação neuronal. CONCLUSÃO: Um estímulo que crie PA, se aplicado de maneira constante, pode reduzir a frequência de despolarizações em função do tempo e, consequentemente, adaptar a célula. O tempo que a célula demora, na ausência de estímulos, para recuperar sua frequência original é definido como desadaptação.

INTRODUCTION: The action potential (AP) arises due to a disturbance of the resting state of the cell membrane with consequent flow of ions across the membrane and ion concentration changes in intra and extra cellular space. OBJECTIVES: This article aims to summarize the scientific knowledge accumulated to date on the action potential and neural adaptation in the process of applying a constant stimulus. MATERIALS AND METHODS: This is a literature review on the bases Springer, ScienceDirect, PubMed, IEEE Xplore, Google Scholar, Capes Periodicals Portal as well as books on the topic. The selected preferred language was English with the keywords: action potential; adaptation, accommodation; rheobase; chronaxy; nerve impulse. We conducted a search of articles with a wide time window from 1931 to 2010 and books from 1791 to 2007. RESULTS: In the selected studies was extracted information about the following topics: action potential and its stages; nerve conduction; rheobase; chronaxie, accommodation, and adaptation. CONCLUSION: A stimulus that creates AP, if applied consistently, can reduce the frequency of depolarization as a function of time and, consequently, to adapt the cell. The time it takes the cell in the absence of stimuli, to recover its original frequency, is defined as a disadaptation.

Sistemas implantáveis de estimulação elétrica funcional para controle artificial de movimentos funcionais: [revisão] / Implantable functional electrical stimulation systems for artificially controlling functional movements: [review]

Pessoas com lesão no sistema nervoso central (SNC), particularmente após lesão medular e acidente vascularencefálico podem apresentar limitação na capacidade de realização das atividades da vida diária incluindo alocomoção. A estimulação elétrica funcional (FES) promove a contração dos músculos paralisados/paréticos e permite realizar essas tarefas funcionais. O objetivo deste trabalho éapresentar uma revisão dos sistemas artificiais de controle motor implantáveis desenvolvidos para minimizar os efeitos das incapacidades causadas pela lesão e de outras como asdecorrentes de acidente vascular encefálico. Buscas foram feitas no serviço online Google Acadêmico, resultando na compilação de base com 259 artigos. Os estimuladores elétricossão classificados em quatro categorias, dependendo da localização dos eletrodos e da topologia do sistema: externos ou não-invasivos que utilizam eletrodos de superfície, hard-wired implantados com acoplamento transcutâneo, e totalmente implantados. O estimulador elétrico mais antigocitado é de 1961 e o mais recente é de 2008. Os estimuladores elétricos descritos foram eficazes para realizar artificialmente movimentos funcionais. Transdutores de várias naturezas foram empregados em sistemas de malha aberta e fechada. Sistemas de malha fechada tiveram maior incidência nos estimuladores elétricos mais recentes. Estimuladores elétricos totalmente implantados e com acoplamento transcutâneo apresentaram menos problemas com quebras de eletrodos e problemas de infecção do que os hard-wired. As estratégias de estimulação envolveram controle ativado tanto pelo paciente quanto automático. Depósitos de patente também são apresentados. A redução de dispositivos que permanecerão internos a dimensões injetáveis favorece os sistemas de FES com acoplamento transcutâneo. Pesquisas científicas de alta tecnologia buscam desenvolver microestimuladores injetáveis com novos materiais isolantese técnicas de implante menos invasivas...

After suffering a spinal trauma, people with spinal cord injury become unable to perform several daily life activities. The aim of this study is to present a review of artificial motor control systemsdeveloped to minimize the effects of this impairment. A 259-paper database was compiled from the results of queries submitted to Google Scholar online service. Electrical stimulators are classified in four categories according to electrodes placement and systemtopology: external or non-invasive which use surface electrodes, hard-wired, implanted with transcutaneous coupling, and totally implanted. The oldest electrical stimulator cited dates back to 1961 and the most recent is from 2008. The described electrical stimulators were efficient for performing artificial functionalmovements. Transducers of different natures were used in open and closed loop systems. Totally implanted and transcutaneously coupled electrical stimulators showed less electrode failures and infection problems than hard-wired systems. In recent electricalstimulators, closed loop systems are more incident. Patent deposits are also presented. The physical reduction of components and units to injectable dimensions favors transcutaneously coupled electrical stimulators. High technology scientific researches aim to develop injectable micro stimulators with new insulation materials and less invasive implantation techniques. For implantable systems, before performing the implant it is required to test the efficacy and to consider the control strategy practicality. This fact also leads to the need of developing new techniques for communicating more efficiently between implantable electrical stimulators and the external control units.

In site electric field measurementos in hospital operating rooms / Medição de campos elétricos in situ em centros cirúrgicos

A interferência eletromagnética pode causar problemas no funcionamento de equipamentos eletromédicos. Dentre as fontes radiantes de interferência encontradas na literatura, os telefones celulares e as unidades eletrocirúrgicas vêm recebendo atenção especial. Rotineiramente, essas fontes operam simultaneamente em pequenos espaços físicos, como as salas cirúrgicas. Este estudo apresenta uma sondagem da intensidade de campo elétrico ambiente em salas cirúrgicas durante a intervenção médica. As medições aconteceram em centros cirúrgicos de três hospitais com o emprego de um medidor isotrópicos de campo elétrico com sensor calibrado. Sete diferentes tipos de cirurgia foram monitorados. Para evitar a obtenção de intensidades de campo discrepantes nas medições, os experimentos aconteceram nas salas cirúrgicas disponíveis que apresentaram disposição similaar de objetos e móveis cirúrgicos e equipamentos eletromédicos. O medidor de campo adquiriu as medidas em quatro pontos ao redor da mesa cirúrgica. A comunicação remota entre o medidor dentro da sala cirúrgica e um computador portátil fora da sala foi estabelecida por meio de um cabo de fibra ótica. Quinze minutos em cado ponto totalizaram 1 hora de observação por cirurgia. O medidor registrou valores de campo elétrico mais elevados que o nível basal quando do acionamento da unidade eletrocirúrgica. O valor médio de campo elétrico variou entre 1,1 mais ou menos 0,3 V/m e 3,0 mais ou menos 1,2 V/m. Contudo, intensidades mais elevadas de campo elétrico foram observadas, como 9,1 V/m, para distâncias maiores que 2,0 m. Os campos elétricos registrados resultam da integração de todos os campos existentes no espectro de freqüências que o medidor é capaz de monitorar. Por esse motivo, o medidor não consegue determinar os campos elétricos na freqüência de operação de um equipamento eletrodoméstico específico, diferentemente de um analisador de espectro. Porém, ele apresentou o impacto causado pela ativação da unidade eletro...